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Role of endothelium-derived nitric oxide in the regulation of bllod pressure PDF Stampa E-mail
Monday 26 November 2007

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Role of endothelium-derived nitric oxide in the regulation of

blood pressure

(L-arginine/hypertension/vascular endothelium/endothelium-derived relaxing factor)

D. D. REES, R. M. J. PALMER, AND S. MONCADA

Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, United Kingdom

Communicated by George H. Hitchings, January 27, 1989

ABSTRACT The role of endothelium-derived nitric oxide

in the regulation of blood pressure in the anesthetized rabbit

was studied with Na-monomethyl-L-arginine (L-NMMA), a

specific inhibitor of its formation from L-arginine. L-NMMA

(3-100 mg-kg-'), but not its D-enantiomer, induced a dosedependent

long-lasting (15-90 min) increase in mean systemic

arterial blood pressure. L-NMMA (100 mg kg-') also inhibited

significantly the hypotensive action of acetylcholine, without

affecting that of glyceryl trinitrate. Both these actions of

L-NMMA were reversed by L-arginine (300 mg-kg-'), but not

by D-arginine (300 mg-kg-'), indomethacin (1 mg-kg-'), prazosin

(0.3 mg-kg-'), or by vagotomy. The effects of L-NMMA

in vivo were associated with a significant inhibition of the

release of nitric oxide from perfused aortic segments ex vivo.

This inhibition was reversed by infusing L-arginine through the

aortic segments. These results indicate that nitric oxide formation

from L-arginine by the vascular endothelium plays a

role in the regulation of blood pressure and in the hypotensive

actions of acetylcholine.

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